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Custom chemical synthesis
     

The Custom Synthesis laboratories at Nextar are fully equipped and managed by experienced chemists and highly professional scientific staff to fulfill client requirements through robust and streamlined processes for tight and transparent project management.
 
Nextar's abilities in process chemistry enables the development of economically efficient and proprietary processes that can lead to rapid and fast track development of new drug candidates and lead compounds.
 
Following compound specifications provided by the customer, literature and SciFinder searches in parallel to examination of known synthetic processes are conducted to assist in the evaluation and selection of the best synthetic route.
 
Our custom chemical synthesis services include:

  •  Synthetic processes for preparation of lab-scale quantities of :
    • New chemical entities
    • Active pharmaceutical ingredients
    • Pro-drugs
    • Analogs
    • Intermediates
    • Impurities
    • Metabolites
    • Degradants
    • Reference standards
  • Custom synthesis of small libraries based on scaffolds to improve pharmacological or pharmaceutical properties
  • Synthesis of analogs for structure-activity relationship (SAR) studies
  • Compound optimization using structure-based drug design
 

News


Nextar has completed the integration of a new Ion-exchange chromatograph.
The new device allows the separation of ions and polar molecules based on their charge. It can be used for almost any kind of charged molecule including large proteins, small nucleotides and amino acids (November 2011)
A new service - QP release of imported pharmaceutical batches
Following the ministry of health new regulation, as of April 2011, the release of imported batches manufactured in a country that is not accredited by the International Laboratory Accreditation Cooperation, is under the responsibility of the importer. The batches must be tested and released by a GMP laboratory in an accredited country. Nextar invites all importers to use our QP and Analytical services.
A new Corona Charged Aerosol Detector (CAD) for HPLC
Nextar has completed the integration of a novel universal HPLC detector, the Corona Charged Aerosol Detector (CAD) and has successfully completed the validation of an analytical method for assay and IDD of phospholipids. Based on a unique, innovative detection method, the Corona detector is a robust universal detector with sensitivity that is similar and often better than ELSD. This makes it ideal for determination of low-level impurities, studies of leachables and extractables, or just assay of analytes that are not suitable for UV detection (e.g. phospholipids, carbohydrates etc.).
 
 
       
  Design - Studiommoza

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